Technology

Pioneering the RNAi revolution

RNA interference (RNAi) technology is the genetic medicines modality with the highest degree of human validation. This powerful pharmaceutical technology has experienced a rapid transition from Nobel Prize to marketed products that reversibly silence disease-promoting genes. SanegeneBio operates under the singular vision that RNAi will become standard-of-care for a broad range of disease indications, with the potential to impact longevity and quality-of-life for many.

A digital rendering of a transparent, crystalline molecular structure is shown against a soft blue and white background.
A focused young male Asian scientist wearing a lab coat with the SanegeneBio logo safety goggles and blue gloves examines a vial of liquid

The medical, scientific and patient communities are now witnessing RNAi at a crossroads – from benefitting small populations with genetically-defined diseases to benefitting large numbers of patients with chronic metabolic disorders. SanegeneBio has developed proprietary nucleic acid and targeted delivery technology to enable safe, effective and durable RNAi medicines which can be self-administered as infrequently as two times per year.

Optimized RNAi Payload

Proprietary GalNAc

LEAD™ Technology

LEAD™ Platform for Extrahepatic Delivery
enhancer ()
Tailored Enhancer

PK Modulation
Receptor Affinity
Intracellular Trafficking

linker
Linker
LEAD
LEAD ()
* composition and placement of the ligand and enhancer are unique to each LEAD embodiment
ligands
New Ligands

Small Molecules
Peptides
Antibodies

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Targeted
Delivery
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Muscle
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Adipose
macrophage
Macrophage
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CNS
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Best-in-class potency and durability

Defined receptor-mediated internalization mechanisms for exquisite cell-type selectivity

Clinically validated chemistries for de-risked safety profile

Line-of-sight to commercial-scale manufacturing

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Our Pipeline

We’re advancing a pipeline of best-in-class therapeutics targeting obesity and metabolic disorders, complement-mediated immune diseases, and cardiovascular diseases.